3 research outputs found
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Development of an Automated Multiple Material Stereolithography Machine
An automated Multiple Material Stereolithography (MMSL) machine was developed by
integrating components of a 3D Systems 250/50 stereolithography (SL) machine in a separate
stand-alone system and adapting them to function with additional components required for
MMSL operation. We previously reported retrofitting a 250/50 SL machine with multiple vats
to accommodate multiple material fabrication for building a wide variety of multi-material
models (Wicker et al., 2004). In the MMSL retrofit, spatial constraints limited the multiple vats
located circumferentially on a vertical rotating vat carousel to cross-sectional areas of
approximately 4.5-inches by 4.5-inches. The limited build size of the retrofitted 250/50
motivated the full development of a new system with multiple material build capabilities
comparable to the build envelope of the original 250/50 machine. The new MMSL machine
required fabrication of a large system frame, incorporating various 250/50 components and
software, and adding a variety of new components and software. By using many existing
components and software, the previous engineering development of 3D Systems could be
directly applied to this new technology. Components that were transferred from an existing
250/50 to the MMSL machine included the complete optical system (including the optics plate
with laser, mirrors, beam expander, scanning mirrors, and focusing lens), the rim assembly
(including the laser beam profilers), the associated controllers (computer system, scanning mirror
controller, power supply-vat controller) and the wiring harness. In addition to the new frame, the
MMSL machine required the development of a new rotating vat carousel system, platform
assembly, multi-pump filling/leveling system, and a custom LabVIEW® control system to
provide automated control over the MMSL process. The overall operation of the MMSL system
was managed using the LabVIEW® program, which also included controlling a new vat leveling
system and new linear and rotational stages, while the 3D Systems software (Buildstation 4.0)
was retained for controlling the laser scanning process. As a demonstration of MMSL
technology, simple multi material parts were fabricated with vertically and horizontally oriented
interfaces. The fully functional MMSL system offers enormous potential for fabricating a wide
variety of multiple material functional devices.Mechanical Engineerin
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Hybrid Manufacturing: Integrating Direct Write and Stereolithography
A commercial stereolithography (SL) machine was modified to integrate fluid dispensing or
direct-write (DW) technology with SL in an integrated manufacturing environment for
automated and efficient hybrid manufacturing of complex electrical devices, combining threedimensional (3D) electrical circuitry with SL-manufactured parts. The modified SL system
operates similarly to a commercially available machine, although build interrupts were used to
stop and start the SL build while depositing fluid using the DW system. An additional linear
encoder was attached to the SL platform z-stage and used to maintain accurate part registration
during the SL and DW build processes. Individual STL files were required as part of the
manufacturing process plan. The DW system employed a three-axis translation mechanism that
was integrated with the commercial SL machine. Registration between the SL part, SL laser and
the DW nozzle was maintained through the use of 0.025-inch diameter cylindrical reference
holes manufactured in the part during SL. After depositing conductive ink using DW, the SL
laser was commanded to trace the profile until the ink was cured. The current system allows for
easy exchange between SL and DW in order to manufacture fully functional 3D electrical
circuits and structures in a semi-automated environment. To demonstrate the manufacturing
capabilities, the hybrid SL/DW setup was used to make a simple multi-layer SL part with
embedded circuitry. This hybrid system is not intended to function as a commercial system, it is
intended for experimental demonstration only. This hybrid SL/DW system has the potential for
manufacturing fully functional electromechanical devices that are more compact, less expensive,
and more reliable than their conventional predecessors, and work is ongoing in order to fully
automate the current system.Mechanical Engineerin
Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study
Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life